Migraines & Jaw Clenching (TMJ)

• Chronic migraines

• Jaw clenching / masseter hypertrophy / TMJ-related pain

How it happens (Simplified)

Chronic migraine is a complex neurologic disorder involving central sensitization, trigeminal nerve activation, and release of neuropeptides like CGRP that drive neurogenic inflammation and pain. Botulinum toxin appears to reduce peripheral sensitization by blocking release of pain mediators at neuromuscular junctions and nerve endings, which in turn may reduce central sensitization over time.(using general neuromodulator data; migraine pathophysiology literature follows similar mechanisms)

Jaw clenching (masseter overactivity)
Bruxism and clenching involve repetitive, often unconscious contraction of the masseter and temporalis muscles, influenced by neuromuscular and sometimes psychological factors. Chronic overactivity leads to hypertrophy of the masseter and pain in the teeth, jaw joints, and surrounding structures.NCBI+1

Severity & treatment approach

• Mild: conservative measures (physiotherapy, splints, stress modification) form the base.

• Moderate–severe, especially with functional impairment or pain: botulinum toxin into the masseter is an accepted option to reduce muscle activity and bulk, usually in conjunction with dental or TMJ care.